Following his fellowships, Dr. Kuppermann joined UCI and has been on faculty since 1992. Currently he is an Associate Professor and Chief of the Retina Service. He served as Acting Chairman of the Department of Ophthalmology from September 1995 to April 1996, and Interim Chairman from July 1, 1996 to December 1998. Dr. Kuppermann is the principal investigator at UCI for several multicenter national trials evaluating new drugs and devices for the treatment of diabetic retinopathy, age-related macular degeneration, and the ocular complications of AIDS. He is the national and international lead investigator for several of these trials.

Dr Kuppermann is listed as one of the best doctors in America, and for the last several years in a row has been named as the "Best Ophthalmologist in Orange County" by Orange Coast Magazine. Dr. Kuppermann is a peer reviewer for the American Journal of Ophthalmology, Archives of Ophthalmology, Investigative Ophthalmology and Visual Science, Ophthalmology, Retina, Journal of Infectious Diseases, Lancet, and the Journal of Obstetrics and Gynecology.

After completing his Ph.D. in neuroscience at the California Institute of Technology (Cal Tech), Dr. Kuppermann went on to earn an M.D. at the University of Miami. He interned at LA County/USC Medical Center and did his residency in ophthalmology at USC’s Doheny Eye Institute. Dr. Kuppermann then went on to complete fellowships in Retina at both St. Joseph’s in Baltimore Maryland, and at the University of California, San Diego.